CNR1 Rabbit pAb (一抗) - WB,IHC-P,IHC-F,IF | Bioss
货号：bs-1683R
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常见问题
概述
产品编号
bs-1683R
产品类型
宠物抗体、农牧业/家禽抗体
英文名称
CNR1 Rabbit pAb
中文名称
钙粘蛋白相关的神经受体1抗体
英文别名
CANN6; CB-R; CB1; CB1A; CB1K5; CB1R; CNR;
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human CNR-1: 401-472/472
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
52 kDa
检测分子量
52 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
Cardiovascular > Atherosclerosis > Lipoprotein metabolism
Cardiovascular > Lipids / Lipoproteins > Lipid Metabolism > Cholesterol Metabolism
Metabolism > Pathways and Processes > Metabolic signaling pathways > Lipid and lipoprotein metabolism > Cholesterol Metabolism
Metabolism > Pathways and Processes > Metabolic signaling pathways > Lipid and lipoprotein metabolism > Lipoprotein metabolism
Metabolism > Types of disease > Heart disease
Neuroscience > Neurotransmission > Receptors / Channels > GPCR > Cannabinoid Receptor
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍
CB1又称大麻素受体1,可导致大麻素类物质作用及代谢异常,从而影响胃肠动力及感觉.
背景资料
This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq, May 2009]
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Rat | Human, Mouse, Rabbit, Pig, Cow, Dog, GuineaPig, Horse | 1:500-2000 |
| IHC-P | Rat | Human, Mouse, Rabbit, Pig, Cow, Dog, GuineaPig, Horse | 1:100-500 |
| IHC-F | Rat | Human, Mouse, Rabbit, Pig, Cow, Dog, GuineaPig, Horse | 1:100-500 |
| IF | Rat | Human, Mouse, Rabbit, Pig, Cow, Dog, GuineaPig, Horse | 1:100-500 |
交叉反应
交叉反应: Rat (predicted: Human, Mouse, Rabbit, Pig, Cow, Dog, GuineaPig, Horse)
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靶标
基因名
CNR1
蛋白名
Cannabinoid receptor 1
亚基
Interacts (via C-terminus) with CNRIP1.
亚细胞定位
Cell membrane.
组织特异性
Widely expressed.
相似性
Belongs to the G-protein coupled receptor 1 family.
功能
Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding.
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