紧密连接蛋白1重组兔单抗
KO/KD Validated
Rrmab®兔单抗
货号：bsm-60433R
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概述
产品编号
bsm-60433R
产品类型
重组兔单抗、KO/KD Validated
英文名称
CLDN1 Recombinant Rabbit mAb
中文名称
紧密连接蛋白1重组兔单抗
英文别名
CLD1; ILVASC; SEMP1; CLD1_HUMAN; CLDN1; Senescence-associated epithelial membrane protein;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human Claudin 1: 180-211
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
B5D10
理论分子量
23 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍
Claudin 1蛋白是紧密连接区相关的转膜蛋白Claudin的家族成员，在构成紧密连接的完整膜蛋白中发挥着一定作用，目前多用于肿瘤方面的研究。
背景资料
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome. [provided by RefSeq, Jul 2008]
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Mouse | 1:500-2000 |
交叉反应
交叉反应: Human, Mouse
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靶标
基因名
CLDN1
蛋白名
Claudin-1
亚基
Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN3, but not CLDN2, homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3. Interacts with MPDZ and INADL.
亚细胞定位
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
组织特异性
Widely expressed, with highest levels in liver and kidney.
相似性
Belongs to the claudin family.
功能
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
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具体参考文献:bsm-60433R 被引用于6文献中
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