API5 Rabbit pAb (一抗) | Bioss
货号：bs-1252R
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常见问题
概述
产品编号
bs-1252R
产品类型
宠物抗体、农牧业/家禽抗体
英文名称
API5 Rabbit pAb
中文名称
凋亡抑制因子5抗体
英文别名
AAC-11; AAC11; API-5; API5_HUMAN; API5; Antiapoptosis clone 11 protein (AAC-11); Cell migration-inducing gene 8 protein; Fibroblast growth factor 2-interacting factor (FIF); Protein XAGL; API5_MOUSE;
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human API5: 351-460/504
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
57 kDa
检测分子量
57 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
IAP-5是细胞凋亡的一种抑制因子、参与细胞凋亡调控，可以用于各种恶性肿瘤的细胞凋亡的研究.
背景资料
Apoptosis inhibitor 5 (API5) is an antiapoptotic factor which may have a role in protein assembly. API5 expression is often upregulated in tumor cells, particularly in metastatic cells. It is a critical determinant of E2F1-induced apoptosis, acting downstream of E2F to suppress E2F-dependent apoptosis without generally blocking E2F-dependent transcription. Alternate Names: AAC 11; AAC11; Antiapoptosis clone 11 protein; API 5; API5; API5 like 1; API5L1; Cell migration inducing gene 8 protein; Fibroblast growth factor 2 interacting factor 2; FIF; MIG 8; MIG8; Migration inducing protein MIG8; Protein XAGL.
Function : Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Mouse | Human, Rat, Pig, Cow, Dog, GuineaPig, Horse | 1:500-2000 |
| IHC-P | Mouse, Rat | Human, Pig, Cow, Dog, GuineaPig, Horse | 1:100-500 |
| IHC-F | Mouse, Rat | Human, Pig, Cow, Dog, GuineaPig, Horse | 1:100-500 |
| IF | Mouse, Rat | Human, Pig, Cow, Dog, GuineaPig, Horse | 1:100-500 |
交叉反应
交叉反应: Mouse, Rat (predicted: Human, Pig, Cow, Dog, GuineaPig, Horse)
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靶标
基因名
API5
蛋白名
Apoptosis inhibitor 5
亚基
Monomer. Interacts with FGF2 and ACIN1.
亚细胞定位
Nucleus. Cytoplasm. Note=Mainly nuclear. Can also be cytoplasmic.
Isoform 3: Cytoplasm.
Isoform 3: Cytoplasm.
组织特异性
Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highest levels in heart, pancreas and placenta. Highly expressed in several cancers. Preferentially expressed in squamous cell carcinoma versus adenocarcinoma in non-small cell lung cancer.
翻译后修饰
Acetylation at Lys-251 impairs antiapoptotic function.
相似性
Belongs to the API5 family.
功能
Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs.
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