FOXA2 Mouse mAb (一抗) | Bioss
货号：bsm-33900M
产品详情
相关标记
相关产品
相关文献
常见问题
概述
产品编号
bsm-33900M
英文名称
FOXA2 Mouse mAb
中文名称
肝细胞核因子3单克隆抗体
英文别名
HNF-3-beta; HNF3B; TCF3B; HNF3-beta; HNF3beta; Hnf-3b; Tcf-3b; FOXA2_HUMAN; FOXA2; Forkhead box protein A2; Transcription factor 3B (TCF-3B); FOXA2_MOUSE; FOXA2_RAT; forkhead box A2; hepatocyte nuclear factor 3, beta
抗体来源
Mouse
免疫原
Recombinant human FoxA2 protein
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Monoclonal
克隆号
8F12
理论分子量
50 kDa
检测分子量
50 kDa
浓度
1mg/ml
储存液
0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008]
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | 1:500-2000 |
交叉反应
交叉反应: Human
相关产品
暂无相关产品
靶标
基因名
FOXA2
蛋白名
Hepatocyte nuclear factor 3-beta
亚基
Binds DNA as a monomer. Binds TLE1. Interacts with FOXA1 and FOXA3. Interacts with PRKDC.
亚细胞定位
Nucleus. Cytoplasm.
翻译后修饰
Phosphorylation on Thr-156 abolishes binding to target promoters and subsequent transcription activation upon insulin stimulation.
相似性
Contains 1 fork-head DNA-binding domain.
功能
Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3'. In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally discribed as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.
同靶标产品
相关文献
提示: 发表研究结果有使用 bsm-33900M 时请让我们知道，以便我们可以引用参考文章。作为回馈，资料提供者将获得我们送上的小礼品。