phospho-PBK (Thr9) Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF | Bioss
Rrmab?兔单抗
货号：bsm-62741R
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概述
产品编号
bsm-62741R
产品类型
磷酸化抗体、重组兔单抗
英文名称
phospho-PBK (Thr9) Recombinant Rabbit mAb
中文名称
磷酸化PDZ连接激酶/T-LAK细胞源蛋白激酶重组兔单抗
英文别名
PBK (phospho-T9); p-PBK; phospho-PBK; PBK (phospho-Thr9); CT84; HEL164; Nori-3; SPK; TOPK; TOPK_HUMAN; PBK; Cancer/testis antigen 84 (CT84); MAPKK-like protein kinase; PDZ-binding kinase; Spermatogenesis-related protein kinase (SPK); T-LAK cell-originated protein kinase; 2.7.12.2;
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human PBK around the phosphorylation site of T9: FK-pT-PS
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
9C3
理论分子量
36 kDa
检测分子量
40 kDa
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
Cancer > Cell cycle > Cell cycle inhibitors > p53 pathway
Cell Biology > Cell Cycle > Cell Cycle Inhibitors > p53
Cell Biology > Cell Cycle > Cell Division > Cytokinesis
Epigenetics and Nuclear Signaling > DNA / RNA > DNA Damage & Repair > DNA Damage Response > p53
Signal Transduction > Protein Phosphorylation > Ser / Thr Kinases > MAPK Pathway
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍
PBK/TOPK是一种新近发现的丝-苏氨酸激酶,属于MAPKK分子家族成员，具有参与调控恶性肿瘤细胞的增殖和周期变化, 促进肿瘤细胞转化, 并且通过MAPKK信号通路参与调控细胞DNA损伤修复.
背景资料
Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | 1:500-2000 | |
| IHC-P | Human | 1:50-200 | |
| IHC-F | Human | 1:50-200 | |
| IF | Human | 1:50-200 |
交叉反应
交叉反应: Human
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靶标
基因名
PBK
蛋白名
Lymphokine-activated killer T-cell-originated protein kinase
亚基
Interacts with DLG1 and TP53.
组织特异性
Expressed in the testis and placenta. In the testis, restrictedly expressed in outer cell layer of seminiferous tubules.
翻译后修饰
Phosphorylated; in a cell-cycle dependent manner at mitosis.
相似性
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase kinase subfamily.
Contains 1 protein kinase domain.
Contains 1 protein kinase domain.
功能
Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage.
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