May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts.
产品应用
应用
已检合格种属
预测种属
推荐稀释比例
WB
Human, Mouse, Rat
1:500-2000
IHC-P
Human, Mouse, Rat
1:100-500
IHC-F
Human, Mouse, Rat
1:100-500
IF
Human, Mouse, Rat
1:100-500
Flow-Cyt
Human
Mouse, Rat
1:50-100
交叉反应
交叉反应: Human, Mouse, Rat
相关产品
暂无相关产品
靶标
基因名
APLP2
蛋白名
Amyloid-like protein 2
亚基
Interacts with CPEB1.
亚细胞定位
Cell membrane. Nucleus.
组织特异性
Expressed in placenta, brain, heart, lung, liver, kidney and endothelial tissues.
翻译后修饰
The BPTI/Kunitz inhibitor domain is O-glycosylated.
相似性
Belongs to the APP family. Contains 1 BPTI/Kunitz inhibitor domain.
功能
May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein.