Munc18-1 Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF | Bioss
Rrmab?兔单抗
货号：bsm-62220R
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概述
产品编号
bsm-62220R
产品类型
重组兔单抗
英文名称
Munc18-1 Recombinant Rabbit mAb
中文名称
神经突触前膜胞内蛋白18重组兔单抗
英文别名
DEE4; MUNC18-1; N-Sec1; NSEC1; P67; RBSEC1; UNC18; unc-18A; unc18-1; MMS10-G; Ms10g; Munc-18a; Rb-sec1; Sxtbp1; Unc18h; ANC18HA; NSEC1A; Sec1; rbSec1A; rbSec1B; unc-18-1; STXB1_CHICK; STXBP1; Protein unc-18 homolog 1 (Unc18-1); Protein unc-18 homolog A (Unc-18A); UNC18A; STXB1_HUMAN; STXB1_MOUSE; STXB1_RAT; syntaxin binding protein 1; syntaxin-binding protein 1
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human Syntaxin binding protein 1: 440-492
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
9B3
理论分子量
68 kDa
检测分子量
68 kDa
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
Cancer > Cancer Metabolism > Metabolic signaling pathway > Integration of energy metabolism
Metabolism > Pathways and Processes > Metabolic signaling pathways > Energy transfer pathways > Integration of energy
Metabolism > Types of disease > Cancer
Neuroscience > Cell Type Marker > Neuron marker > Synapse marker
Neuroscience > Neurotransmission > Secretory Vesicles > Munc18
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | Mouse, Rat | 1:500-2000 |
| IHC-P | Human, Mouse, Rat | 1:100-500 | |
| IHC-F | Human, Mouse, Rat | 1:100-500 | |
| IF | Human, Mouse, Rat | 1:100-500 |
交叉反应
交叉反应: Human, Mouse, Rat
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暂无相关产品
靶标
基因名
STXBP1
蛋白名
Syntaxin-binding protein 1
亚基
Binds SYTL4. Interacts with STX1A.
亚细胞定位
Cytoplasm. Membrane; Peripheral membrane protein.
组织特异性
Brain and spinal cord. Highly enriched in axons.
疾病
Defects in STXBP1 are the cause of epileptic encephalopathy early infantile type 4 (EIEE4) [MIM:612164]. Affected individuals have neonatal or infantile onset of seizures, suppression-burst pattern on EEG, profound mental retardation, and MRI evidence of hypomyelination.
相似性
Belongs to the STXBP/unc-18/SEC1 family.
功能
May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions.
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