GNL3 Recombinant Rabbit mAb (一抗) - WB,Flow-Cyt,ICC/IF | Bioss
Rrmab?兔单抗
货号：bsm-61946R
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概述
产品编号
bsm-61946R
产品类型
重组兔单抗
英文名称
GNL3 Recombinant Rabbit mAb
中文名称
鸟嘌呤核苷酸结合蛋白3重组兔单抗
英文别名
C77032; E2IG3; NNP47; NS; Nug1; GNL3_HUMAN; GNL3; E2-induced gene 3 protein; Novel nucleolar protein 47 (NNP47); Nucleolar GTP-binding protein 3; Nucleostemin; GNL3_MOUSE; GNL3_RAT; G protein nucleolar 3; guanine nucleotide binding protein-like 3 (nucleolar)
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human GNL3: 500-549/549
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
13E15
理论分子量
62 kDa
检测分子量
62 kDa
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | 1:500-2000 | |
| Flow-Cyt | Human | 1:50-100 | |
| ICC/IF | Human | 1:50-200 |
交叉反应
交叉反应: Human
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靶标
基因名
GNL3
蛋白名
Guanine nucleotide-binding protein-like 3
亚基
Interacts with MDM2; this interaction stabilizes MDM2. Interaction with MDM2 occurs in the nucleoplasm and is triggered by a nucleolar release mechanism, such as mitosis-induced nucleolar disassembly (By similarity). Indirectly interacts with TP53, via MDM2-binding (By similarity).
亚细胞定位
Nucleus. Nucleus. nucleolus. Shuttles between the nucleus and nucleolus.
组织特异性
Increased levels in lung tissue in cancer patients.
相似性
Belongs to the MMR1/HSR1 GTP-binding protein family.
Contains 1 G (guanine nucleotide-binding) domain.
Contains 1 G (guanine nucleotide-binding) domain.
功能
May be required to maintain the proliferative capacity of stem cells and may play an important role in tumorigenesis.
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