Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. [provided by RefSeq, Jul 2008]
产品应用
应用
已检合格种属
预测种属
推荐稀释比例
WB
Human, Mouse, Rat
1:500-2000
IHC-P
Human, Rat
Mouse
1:100-500
IHC-F
Human, Rat
Mouse
1:100-500
IF
Human, Rat
Mouse
1:100-500
交叉反应
交叉反应: Human, Mouse, Rat
相关产品
暂无相关产品
靶标
基因名
F2R
蛋白名
Proteinase-activated receptor 1
亚细胞定位
Cell membrane; Multi-pass membrane protein.
组织特异性
Platelets and vascular endothelial cells.
翻译后修饰
A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand. Phosphorylated; probably mediating desensitization prior to the uncoupling and internalization of the receptor.
相似性
Belongs to the G-protein coupled receptor 1 family.
功能
High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.