PCGF4/BMI1 Recombinant Rabbit mAb (一抗) | Bioss
Rrmab?兔单抗
货号：bsm-61372R
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概述
产品编号
bsm-61372R
产品类型
重组兔单抗
英文名称
PCGF4/BMI1 Recombinant Rabbit mAb
中文名称
组蛋白相关Bmi1重组兔单抗
英文别名
BMI1; PCGF4; RNF51; FLVI2/BMI1; flvi-2/bmi-1; Bmi-1; BMI1_HUMAN; Polycomb group RING finger protein 4; RING finger protein 51; BMI1_MOUSE; BMI1 proto-oncogene, polycomb ring finger; polycomb group ring finger 4; B lymphoma Mo-MLV insertion region 1 homolog (mouse)
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human BMI1: 302-326
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
19B13
理论分子量
37 kDa
检测分子量
41 kDa
储存液
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究领域
Cancer > Cell cycle > Cell differentiation
Cancer > Oncoproteins/suppressors > Oncoproteins
Cell Biology > Cell Cycle > Cell differentiation
Epigenetics and Nuclear Signaling > Chromatin Remodeling > Polycomb Silencing > PRC2
Epigenetics and Nuclear Signaling > Transcription > Cancer susceptibility > Proto-oncogenes
Stem Cells > Hematopoietic Progenitors > Intracellular Molecules
SWISS
Gene ID
保存条件
Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | Rat | 1:500-2000 |
交叉反应
交叉反应: Human (predicted: Rat)
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暂无相关产品
靶标
基因名
BMI1
蛋白名
Polycomb complex protein BMI-1
亚细胞定位
Nucleus. Cytoplasm.
翻译后修饰
Monoubiquitinated. May be polyubiquitinated; which does not lead to proteasomal degradation.
相似性
Contains 1 RING-type zinc finger.
功能
Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.
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