STMN1 Mouse mAb (一抗) - IHC-P,IHC-F,IF | Bioss
货号：bsm-34184M
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概述
产品编号
bsm-34184M
产品类型
mIHC精品抗体
英文名称
STMN1 Mouse mAb
中文名称
白血病相关蛋白18/癌蛋白18单克隆抗体
英文别名
C1orf215; LAP18; Lag; OP18; PP17; PP19; PR22; SMN; 19k; P18; P19; Pig; Pp18; prosolin; STMN1_HUMAN; STMN1; Leukemia-associated phosphoprotein p18; Metablastin; Oncoprotein 18 (Op18); Phosphoprotein p19 (pp19); Protein Pr22; STMN1_MOUSE; Leukemia-associated gene protein; STMN1_RAT; Pr22 protein; stathmin 1; chromosome 1 open reading frame 215; stathmin 1/oncoprotein 18; oncoprotein 18
抗体来源
Mouse
免疫原
KLH conjugated synthetic peptide derived from human Stathmin 1
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Monoclonal
克隆号
14F6
理论分子量
17 kDa
浓度
1mg/ml
储存液
0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
原癌基因蛋白18(oncogene protein 18,Op18),是一种广泛存在于细胞质的蛋白质,可与微管蛋白结合,参与微管和纺锤体的组装;与细胞的增殖、分化、再生和运动均有关,并具有信号活性调节的功能。在细胞增殖、分化的信号途径、传到通路激活中也具有多种调节功能。
近年来有研究发现,stathmin在多种肿瘤中高表达,并可通过调节微管的解聚,促进肿瘤细胞的运动及侵袭。Stathmin翻译后修饰状态的改变,可影响与p53蛋白的相互作用,参与肿瘤的发生发展.
近年来有研究发现,stathmin在多种肿瘤中高表达,并可通过调节微管的解聚,促进肿瘤细胞的运动及侵袭。Stathmin翻译后修饰状态的改变,可影响与p53蛋白的相互作用,参与肿瘤的发生发展.
背景资料
This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| IHC-P | Human | 1:100-500 | |
| IHC-F | Human | 1:100-500 | |
| IF | Human | 1:100-500 |
交叉反应
交叉反应: Human
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靶标
基因名
STMN1
蛋白名
Stathmin
亚基
Binds to two alpha/beta-tubulin heterodimers. Interacts with KIST.
亚细胞定位
Cytoplasm; cytoskeleton.
组织特异性
Ubiquitous. Expression is strongest in fetal and adult brain, spinal cord, and cerebellum, followed by thymus, bone marrow, testis, and fetal liver. Expression is intermediate in colon, ovary, placenta, uterus, and trachea, and is readily detected at substantially lower levels in all other tissues examined. Lowest expression is found in adult liver. Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes, non-leukemic proliferating lymphoid cells, bone marrow cells, or cells from patients with chronic lymphoid or myeloid leukemia.
翻译后修饰
Many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF. Phosphorylation at Ser-16 seems to be required for neuron polarization. Phosphorylation at Ser-63 reduces tubulin binding 10-fold and suppresses the MT polymerization inhibition activity.
相似性
Belongs to the stathmin family.
功能
Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear.
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