Synaptophysin Mouse mAb (一抗) - WB | Bioss
货号：bsm-51494M
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概述
产品编号
bsm-51494M
产品类型
帕金森相关抗体
英文名称
Synaptophysin Mouse mAb
中文名称
Synaptophysin单克隆抗体
英文别名
MRX96; MRXSYP; XLID96; A230093K24Rik; Syn; p38; Syp1; SYPH_BOVIN; SYP; Major synaptic vesicle protein p38; SYPH_HUMAN; SYPH_MOUSE; BM89 antigen; SYPH_RAT; synaptophysin
抗体来源
Mouse
免疫原
KLH conjugated synthetic peptide derived from human Synaptophysin: 201-300/313
亚型
IgG1, k
性状
Liquid
纯化方法
affinity purified by Protein G
克隆类型
Monoclonal
克隆号
G7F8
理论分子量
34 kDa
检测分子量
40 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
This gene encodes an integral membrane protein of small synaptic vesicles in brain and endocrine cells. The protein also binds cholesterol and is thought to direct targeting of vesicle-associated membrane protein 2 (synaptobrevin) to intracellular compartments. Mutations in this gene are associated with X-linked mental retardation (XLMR). [provided by RefSeq, Aug 2011]
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Mouse, Rat | Human | 1:500-2000 |
交叉反应
交叉反应: Mouse, Rat (predicted: Human)
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靶标
基因名
SYP
蛋白名
Synaptophysin
亚细胞定位
Cytoplasmic vesicle > secretory vesicle > synaptic vesicle membrane. Cell junction > synapse > synaptosome.
组织特异性
Characteristic of a type of small (30-80 nm) neurosecretory vesicles, including presynaptic vesicles, but also vesicles of various neuroendocrine cells of both neuronal and epithelial phenotype.
翻译后修饰
Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.
疾病
Defects in SYP are the cause of mental retardation X-linked SYP-related (MRXSYP) [MIM:300802]. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period.
相似性
Belongs to the synaptophysin/synaptobrevin family. Contains 1 MARVEL domain.
功能
Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity.
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