Occludin Recombinant Rabbit mAb (一抗) - WB,Flow-Cyt,IP | Bioss
Rrmab?兔单抗
货号：bsm-61062R
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概述
产品编号
bsm-61062R
产品类型
重组兔单抗
英文名称
Occludin Recombinant Rabbit mAb
中文名称
紧密连接蛋白重组兔单抗
英文别名
Ocl; BLCPMG; PPP1R115; PTORCH1; OCLN_CANLF; OCLN; OCLN_HUMAN; OCLN_MOUSE; OCLN_RAT; occludin; tight junction protein occludin TM4 minus; phosphatase 1, regulatory subunit 115
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human Occludin: 1-36
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
3C7
理论分子量
57 kDa
检测分子量
65 kDa
储存液
0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
This gene encodes an integral membrane protein that is required for cytokine-induced regulation of the tight junction paracellular permeability barrier. Mutations in this gene are thought to be a cause of band-like calcification with simplified gyration and polymicrogyria (BLC-PMG), an autosomal recessive neurologic disorder that is also known as pseudo-TORCH syndrome. Alternative splicing results in multiple transcript variants. A related pseudogene is present 1.5 Mb downstream on the q arm of chromosome 5. [provided by RefSeq, Apr 2011]
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Mouse, Rat | Human | 1:500-2000 |
| Flow-Cyt | Human, Mouse, Rat | 1:100-200 | |
| IP | Human, Mouse, Rat | 1:50-200 |
交叉反应
交叉反应: Mouse, Rat (predicted: Human)
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靶标
基因名
OCLN
蛋白名
Occludin
亚基
Interacts with TJP1/ZO1 and with VAPA.
亚细胞定位
Membrane; Multi-pass membrane protein. Cell junction, tight junction.
组织特异性
Localized at tight junctions of both epithelial and endothelial cells. Highly expressed in kidney. Not detected in testis.
翻译后修饰
Phosphorylated upon DNA damage, probably by ATM or ATR. Dephosphorylated by PTPRJ. May be phosphorylated by PKC during translocation to cell-cell contacts.
相似性
Belongs to the ELL/occludin family.
Contains 1 MARVEL domain.
Contains 1 MARVEL domain.
功能
May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.
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