Glucose 6 phosphate isomerase Recombinant Rabbit mAb (一抗) | Bioss

Rrmab?兔单抗
2026-05-01~2026-06-30,AB2605
Glucose 6 phosphate isomerase Recombinant Rabbit mAb (一抗) | Bioss
货号:bsm-61012R
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概述

产品编号
bsm-61012R
产品类型
重组兔单抗
英文名称
Glucose 6 phosphate isomerase Recombinant Rabbit mAb
中文名称
糖磷脂酰肌醇重组兔单抗
英文别名
AMF; CNSHA4; GNPI; NLK; PGI; PHI; SA-36; SA36; Gpi; Gpi-1; Gpi-1r; Gpi-1s; Gpi-1t; Gpi1-r; Gpi1-s; Gpi1-t; Gpi1s; MF; NK; NK/GPI; Org; Gpi1; G6PI_HUMAN; Autocrine motility factor (AMF); Neuroleukin (NLK); Phosphoglucose isomerase (PGI); Phosphohexose isomerase (PHI); Sperm antigen 36 (SA-36); 5.3.1.9; G6PI_MOUSE; G6PI_RAT; glucose-6-phosphate isomerase; glucose phosphate isomerase
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human GPI: 1-64/558
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
3A14
理论分子量
63 Da
检测分子量
60 kDa
浓度
1mg/ml
储存液
0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存条件
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍
糖基化磷脂酰肌醇(GPI)锚定蛋白是一种新型细胞表面蛋白,又称:糖基磷脂酰肌醇锚定蛋白质,它只通过GPI结构锚定于细胞膜表面而不跨越其磷脂膜双层结构;当它与细胞共同孵育时,可自动整合至细胞膜表面。GPI锚定蛋白转化法利用GPI锚定信号将目的蛋白直接整合至靶细胞表面,超越了目的蛋白由靶细胞自身合成的机制,具有对靶细胞选择性不高,转化过程迅速等优点.
背景资料
This gene belongs to the GPI family whose members encode multifunctional phosphoglucose isomerase proteins involved in energy pathways. The protein encoded by this gene is a dimeric enzyme that catalyzes the reversible isomerization of glucose-6-phosphate and fructose-6-phosphate. The protein functions in different capacities inside and outside the cell. In the cytoplasm, the gene product is involved in glycolysis and gluconeogenesis, while outside the cell it functions as a neurotrophic factor for spinal and sensory neurons. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment. [provided by RefSeq, Jul 2008].
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产品应用

应用已检合格种属预测种属推荐稀释比例
WBHuman1:500-2000
IHC-PHuman1:100-500
IHC-FHuman1:100-500
IFHuman1:100-500

交叉反应

交叉反应: Human

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靶标

基因名
GPI
蛋白名
Glucose-6-phosphate isomerase
亚基
Homodimer in the catalytically active form, monomer in the secreted form.
亚细胞定位
Cytoplasm. Secreted.
翻译后修饰
Phosphorylation at Ser-185 by CK2 has been shown to decrease enzymatic activity and may contribute to secretion by a non-classical secretory pathway.
ISGylated.
疾病
Defects in GPI are the cause of hemolytic anemia non-spherocytic due to glucose phosphate isomerase deficiency (HA-GPID) [MIM:613470]. It is a form of anemia in which there is no abnormal hemoglobin or spherocytosis. It is caused by glucose phosphate isomerase deficiency. Severe GPI deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment.
相似性
Belongs to the GPI family.
功能
Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons.

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