Cystatin-C Mouse mAb (一抗) | Bioss

2026-05-01~2026-06-30,AB2605
Cystatin-C Mouse mAb (一抗) | Bioss
货号:bsm-43147M
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概述

产品编号
bsm-43147M
英文名称
Cystatin-C Mouse mAb
中文名称
胱抑素C单克隆抗体
英文别名
ADLDWA; ARMD11; HEL-S-2; CysC; CYTC_HUMAN; CST3; Cystatin-3; Gamma-trace; Neuroendocrine basic polypeptide; Post-gamma-globulin; CYTC_MOUSE; CYTC_RAT; A0A8C0SEH9_CANLF; LOC607874; D5MTH1_FELCA;
抗体来源
Mouse
免疫原
Recombinant human Cystatin-C protein: 27-146/146
亚型
IgG
性状
Lyophilized or Liquid
纯化方法
affinity purified by Protein A
克隆类型
Monoclonal
克隆号
9F11
理论分子量
13 kDa
检测分子量
12 kDa
储存液
0.01M PBS(pH7.4)
保存条件
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍
应用推荐(Capture-Detection): 6C1&9E6-1C3

背景资料
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins(stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes the most abundant extracellular inhibitor of cysteine proteases, which is found in high concentrations in biological fluids and is expressed in virtually all organs of the body. A mutation in this gene has been associated with amyloid angiopathy. Expression of this protein in vascular wall smooth muscle cells is severely reduced in both atherosclerotic and aneurysmal aortic lesions, establishing its role in vascular disease. [provided by RefSeq].
胱抑素C单克隆抗体-bsm-43147M

产品应用

应用已检合格种属预测种属推荐稀释比例
WBHuman1:500-2000

交叉反应

交叉反应: Human

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靶标

基因名
LOC607874
蛋白名
Cystatin domain-containing protein
亚基
Expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). Expressed in various body fluids, such as the cerebrospinal fluid and plasma. Expressed in highest levels in the epididymis, vas deferens, brain, thymus, and ovary and the lowest in the submandibular gland.
亚细胞定位
Secreted.
疾病
Defects in CST3 are the cause of amyloidosis type 6 (AMYL6) [MIM:105150]; also known as hereditary cerebral hemorrhage with amyloidosis (HCHWA), cerebral amyloid angiopathy (CAA) or cerebroarterial amyloidosis Icelandic type. AMYL6 is a hereditary generalized amyloidosis due to cystatin C amyloid deposition. Cystatin C amyloid accumulates in the walls of arteries, arterioles, and sometimes capillaries and veins of the brain, and in various organs including lymphoid tissue, spleen, salivary glands, and seminal vesicles. Amyloid deposition in the cerebral vessels results in cerebral amyloid angiopathy, cerebral hemorrhage and premature stroke. Cystatin C levels in the cerebrospinal fluid are abnormally low.
相似性
Belongs to the cystatin family.
功能
As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity.

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