PRAME Rabbit pAb (一抗) | Bioss

2026-03-02~2026-04-30,KXJ26032026-03-02~2026-04-30,促销赠品
PRAME Rabbit pAb (一抗) | Bioss
货号:bs-7004R
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概述

产品编号
bs-7004R
英文名称
PRAME Rabbit pAb
中文名称
黑色素瘤优先表达抗原抗体
英文别名
CT130; MAPE; OIP-4; OIP4; PRAME_HUMAN; PRAME; Opa-interacting protein 4 (OIP-4); Preferentially expressed antigen of melanoma;
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human PRAME: 151-250/509
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
56 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
背景资料
This gene encodes an antigen that is predominantly expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. This expression pattern is similar to that of other CT antigens, such as MAGE, BAGE and GAGE. However, unlike these other CT antigens, this gene is also expressed in acute leukemias. Five alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008]
黑色素瘤优先表达抗原抗体-bs-7004R黑色素瘤优先表达抗原抗体-bs-7004R

产品应用

应用已检合格种属预测种属推荐稀释比例
IHC-PMouseHuman1:100-500
IHC-FMouseHuman1:100-500
IFMouseHuman1:100-500
Flow-CytHumanMouse0.2ug/Test

交叉反应

交叉反应: Human, Mouse

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靶标

基因名
PRAME
蛋白名
Melanoma antigen preferentially expressed in tumors
亚基
Interacts with RARA (via the ligand-binding domain); the interaction is direct and ligand (retinoic acid)-dependent. Interacts with EZH2; required to repress RAR signaling.
亚细胞定位
Nucleus (Probable). Cell membrane.
组织特异性
Expressed in testis. Detected in samples of kidney, brain and skin.
相似性
Belongs to the PRAME family.
Contains 4 LRR (leucine-rich) repeats.
功能
Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis.

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