This gene encodes an antigen that is predominantly expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. This expression pattern is similar to that of other CT antigens, such as MAGE, BAGE and GAGE. However, unlike these other CT antigens, this gene is also expressed in acute leukemias. Five alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008]
产品应用
应用
已检合格种属
预测种属
推荐稀释比例
IHC-P
Mouse
Human
1:100-500
IHC-F
Mouse
Human
1:100-500
IF
Mouse
Human
1:100-500
Flow-Cyt
Human
Mouse
0.2ug/Test
交叉反应
交叉反应: Human, Mouse
相关产品
暂无相关产品
靶标
基因名
PRAME
蛋白名
Melanoma antigen preferentially expressed in tumors
亚基
Interacts with RARA (via the ligand-binding domain); the interaction is direct and ligand (retinoic acid)-dependent. Interacts with EZH2; required to repress RAR signaling.
亚细胞定位
Nucleus (Probable). Cell membrane.
组织特异性
Expressed in testis. Detected in samples of kidney, brain and skin.
相似性
Belongs to the PRAME family. Contains 4 LRR (leucine-rich) repeats.
功能
Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis.