NEFM Recombinant Mouse mAb (一抗) - WB,IHC-P,IHC-F,IF | Bioss
货号：bsm-55531M
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概述
产品编号
bsm-55531M
产品类型
重组小鼠单抗、mIHC精品抗体
英文名称
NEFM Recombinant Mouse mAb
中文名称
中分子量神经丝蛋白重组鼠单抗
英文别名
NEF3; NF-M; NFM; NF160; NF165; NFM_BOVIN; NEFM; 160 kDa neurofilament protein; Neurofilament 3; Neurofilament triplet M protein; NFM_HUMAN; NFM_MOUSE; NFM_RAT; neurofilament medium chain; neurofilament, medium polypeptide 150kDa; neurofilament, medium polypeptide; neurofilament medium
抗体来源
Mouse
免疫原
Recombinant Mouse NF-M protein
亚型
IgG1
性状
Liquid
纯化方法
Affinity Purification
克隆类型
Recombinant
克隆号
SB60
理论分子量
96 kDa
检测分子量
170 kDa
储存液
PBS with 100 μg/ml BSA,0.15% ProClin300 and 50% glycerol.
SWISS
Gene ID
保存条件
Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
哺乳动物的神经丝由3种蛋白组成：低分子量神经丝蛋白，简称NF-L，分子量为68 kDa；中分子量神经丝蛋白，简称NF-M，分子量为160 kDa；高分子量神经丝蛋白，简称NF-H，分子量为200 kDa。神经丝蛋白存在于神经元、神经突起、外周神经纤维、交感神经节细胞和肾上腺髓质。在肿瘤表达于神经母细胞瘤、节细胞性胶质瘤、髓母细胞瘤、视网膜母细胞瘤、松果体实质肿瘤、梅克尔（Merkel）细胞癌、类癌、节细胞性神经母细胞瘤/神经节细胞瘤、胰岛细胞肿瘤、神经母细胞瘤、小细胞癌、副神经节瘤、肾上腺和嗜铬细胞瘤、畸胎瘤伴神经元分化，偶尔表达于Ewing肉瘤/PNET、横纹肌肉瘤、恶性纤维组织细胞瘤、上皮样肉瘤。
背景资料
Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber.May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Mouse | Human, Rat | 1: 500- 2000 |
| IHC-P | Human, Mouse, Rat | 1: 200-500 | |
| IHC-F | Human, Mouse, Rat | 1: 200-500 | |
| IF | Human, Mouse, Rat | 1: 200-500 |
交叉反应
交叉反应: Human, Mouse, Rat
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靶标
基因名
NEFM
蛋白名
Neurofilament medium polypeptide
翻译后修饰
There are a number of repeats of the tripeptide K-S-P, NFM is phosphorylated on a number of the serines in this motif. It is thought that phosphorylation of NFM results in the formation of interfilament cross bridges that are important in the maintenance of axonal caliber.
Phosphorylation seems to play a major role in the functioning of the larger neurofilament polypeptides (NF-M and NF-H), the levels of phosphorylation being altered developmentally and coincidentally with a change in the neurofilament function.
Phosphorylated in the head and rod regions by the PKC kinase PKN1, leading to the inhibition of polymerization.
Phosphorylation seems to play a major role in the functioning of the larger neurofilament polypeptides (NF-M and NF-H), the levels of phosphorylation being altered developmentally and coincidentally with a change in the neurofilament function.
Phosphorylated in the head and rod regions by the PKC kinase PKN1, leading to the inhibition of polymerization.
相似性
Belongs to the intermediate filament family.
功能
Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber.
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