PerCP-Cy5.5标记的表皮生长因子样激素受体1（EMR1）重组兔单抗

bsm-41204R-PerCP-Cy5.5

ADGRE1 Recombinant Rabbit mAb, PerCP-Cy5.5 conjugated

PerCP-Cy5.5标记的表皮生长因子样激素受体1（EMR1）重组兔单抗

F4/80; Adhesion G protein-coupled receptor E1; Cell surface glycoprotein EMR1; Cell surface glycoprotein F4/80; DD7A5 7; Egf like module containing mucin like hormone receptor like 1; Egf like module containing mucin like hormone receptor like sequence 1; EGF like module receptor 1; EGF TM7; EGF-like module receptor 1; EGF-like module-containing mucin-like hormone receptor-like 1; EGFTM7; EMR 1; EMR1; EMR-1; EMR1 hormone receptor; EMR1_HUMAN; AGRE1_HUMAN; Gpf480; Ly71; Lymphocyte antigen 71; TM7LN3.

PerCP-Cy5.5
Excitation spectrum: 482nm
Emission spectrum: 694nm

Rabbit

Recombinant human ADGRE1: 1-530/886

IgG

affinity purified by Protein A

Recombinant

1mg/ml

0.01M TBS (pH7.4) with 1% BSA and 0.02% Proclin300.

Store at 2-8°C for one year. Avoid repeated freeze/thaw cycles.

The epidermal growth factor (EGF)-TM7 family constitutes a group of class B G-protein coupled receptors, which includes CD97, EMR1 (EGF-like molecule containing mucin-like hormone receptor 1, designated F4/80 in mouse), EMR2, EMR3, FIRE, and ETL (1–3). These family members are characterized by an extended extracellular region with several N-terminal EGF domains, and are predominantly expressed on cells of the immune system (1–3). The EGF-TM7 protein family are encoded by a gene cluster on human chromosome 19p13 (1,3,4). The F4/80 molecule is solely expressed on the surface of macrophages and serves as a marker for mature macrophage tissues, including Kupffer cells in liver, splenic red pulp macrophages, brain microglia, gut lamina propria, and Langerhans cells in the skin (1). F4/80/EMR1 undergoes extensive N-linked glycosylation as well as some O-linked glycosylation (5,6). The function of F4/80/EMR1 is unclear, but it is speculated to be involved in macrophage adhesion events, cell migration, or as a G-protein coupled signaling component of macrophages.