CD86抗体
货号：bs-1035R
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概述
产品编号
bs-1035R
英文名称
CD86 Rabbit pAb
中文名称
CD86抗体
英文别名
B7-2; B7.2; B70; CD28LG2; LAB72; CD86_HUMAN; CD86; Activation B7-2 antigen; BU63; CTLA-4 counter-receptor B7.2; FUN-1;
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from the middle of rat CD86: 140-175/313 <Extracellular>
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
31 kDa
检测分子量
72-74 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
Immunology > Adaptive Immunity > Regulatory T Cells
Immunology > Adaptive Immunity > T Cells > CD
Immunology > Cell Type Markers > CD > Non-lineage
Kits/ Lysates/ Other > Kits > ELISA Kits > ELISA Kits > CD markers ELISA kits
Microbiology > Interspecies Interaction > Host Virus Interaction
Stem Cells > Hematopoietic Progenitors > Lymphoid > B Lymphocytic Lineage
Stem Cells > Hematopoietic Progenitors > Myeloid > Dendritic Cell Lineage
Stem Cells > Hematopoietic Progenitors > Myeloid > Monocytic Lineage
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
CD86是一个很重要要的辅助刺激分子，CD86作为CD28的辅助刺激分子，提供 T 细胞活化的辅助信号,它们之间的结合和随后介导的信号转导是 T 细胞和 APC 相互协作的重要分子基础。
背景资料
This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011].
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Mouse, Rat | 1:500-2000 | |
| IHC-P | Human, Rat | Mouse | 1:100-500 |
| IHC-F | Human, Rat | Mouse | 1:100-500 |
| IF | Human, Rat | Mouse | 1:100-500 |
| Flow-Cyt | Human | Mouse, Rat | 1μg/Test |
| ICC/IF | Human | Mouse, Rat | 1:50-200 |
交叉反应
交叉反应: Human, Mouse, Rat
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靶标
基因名
CD86
蛋白名
T-lymphocyte activation antigen CD86
亚基
Homodimer. Interacts with MARCH8. Interacts with human herpesvirus 8 MIR2 protein (Probable). Interacts with adenovirus subgroup B fiber proteins and acts as a receptor for these viruses.
亚细胞定位
Cell membrane; Single-pass type I membrane protein.
组织特异性
Expressed by activated B-lymphocytes and monocytes.
翻译后修饰
Polyubiquitinated; which is promoted by MARCH8 and results in endocytosis and lysosomal degradation.
相似性
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
功能
Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.
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