TMEM119 Mouse mAb (一抗) | Bioss
概述
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Mouse | Human, Rat | 1:500-2000 |
交叉反应
交叉反应: Mouse (predicted: Human, Rat)
相关产品
暂无相关产品
靶标
Cell membrane; Single-pass type I membrane protein; Cytoplasm ;Endoplasmic reticulum membrane
Expressed in brain microglia (at protein level). Elevated expression levels seen in the brain of patients with Alzheimer disease. Expressed by osteoblast-like cells in bone tissues and follicular dendritic cells in lymphoid tissues.
Showing features for signal, chain, glycosylation, modified residue (large scale data), modified residue.
Plays an important role in bone formation and normal bone mineralization. Promotes the differentiation of myoblasts into osteoblasts (PubMed:20025746).
May induce the commitment and differentiation of myoblasts into osteoblasts through an enhancement of BMP2 production and interaction with the BMP-RUNX2 pathway. Up-regulates the expression of ATF4, a transcription factor which plays a central role in osteoblast differentiation. Essential for normal spermatogenesis and late testicular differentiation (By similarity).