The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. The major protein isoforms of this gene differ by the presence or absence of a transmembrane domain and thus differ in being a membrane-anchored or secreted protein. [provided by RefSeq, May 2020]
产品应用
应用
已检合格种属
预测种属
推荐稀释比例
Flow-Cyt
Mouse
10ul/Test
交叉反应
交叉反应: Mouse
相关产品
暂无相关产品
靶标
基因名
CD8A
蛋白名
T-cell surface glycoprotein CD8 alpha chain
亚基
In general heterodimer of an alpha and a beta chain linked by two disulfide bonds. Can also form homodimers.
亚细胞定位
Membrane; Single-pass type I membrane protein.
组织特异性
Most prominently found in the gastrointestinal tract, skin, lung, and brain but not in liver.
Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains.