NSE Mouse mAb (IVD抗体) | Bioss

货号:V1801
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概述

产品编号
V1801
英文名称
NSE Mouse mAb
中文名称
神经元特异性烯醇化酶单克隆抗体
英文别名
Gamma-enolase; Gamma enolase; Neural enolase; Neuron specific enolase; neurone-specific enolase; 2 phospho D glycerate hydrolyase; Eno 2; Eno2; ENO2; ENOG; Enolase 2; Enolase 2 gamma neuronal; Enolase2; Neuron specific enolase; Neuron specific gamma enolase; NSE; ENOG_HUMAN; Gamma-enolase; 2-phospho-D-glycerate hydro-lyase; enolase 2, gamma, neuronal.
抗体来源
Mouse
免疫原
Recombinant human NSE: 1-434/434
亚型
IgG1
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Monoclonal
克隆号
2A8
理论分子量
48 kDa
浓度
≥1mg/ml
储存液
0.01M PBS (pH7.4).
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍
神经元特异性烯醇化酶(NSE)存在于神经元细胞和神经内分泌组织中,起源于神经内分泌细胞的肿瘤可产生过量的NSE。NSE也是小细胞肺癌的检测指标,70%左右的小细胞肺癌患者血中NSE升高,而其他组织型肺癌NSE升高的患者仅为10%~20%。
背景资料
This gene encodes one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates. [provided by RefSeq, Jul 2008].

产品应用

产品应用: ELISA=1:5000-10000, ICA

交叉反应

交叉反应: Human

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靶标

基因名
ENO2
蛋白名
gamma-enolase
亚基
Mammalian enolase is composed of 3 isozyme subunits, alpha, beta and gamma, which can form homodimers or heterodimers which are cell-type and development-specific.
亚细胞定位
Cytoplasm. Cell membrane. Can translocate to the plasma membrane in either the homodimeric (alpha/alpha) or heterodimeric (alpha/gamma) form.
组织特异性
The alpha/alpha homodimer is expressed in embryo and in most adult tissues. The alpha/beta heterodimer and the beta/beta homodimer are found in striated muscle, and the alpha/gamma heterodimer and the gamma/gamma homodimer in neurons.
相似性
Belongs to the enolase family.
功能
Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival.

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