PE标记的人IL-2单克隆抗体

货号:bsm-30228A-PE
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概述

产品编号
bsm-30228A-PE
产品类型
流式抗体
英文名称
human IL-2 Rat mAb, PE conjugated
中文名称
PE标记的人IL-2单克隆抗体
英文别名
Interleukin-2; Interleukin 2; Interleukin2; T-cell growth factor; T Cell Growth Factor; Aldesleukin; IL 2; IL2; Lymphokine; POIL2; T Cell Growth Factor; TCGF; Involved in regulation of T cell clonal expansion; IL2_HUMAN.
标记
PE
Excitation spectrum: 496/564nm
Emission spectrum: 578nm
抗体来源
Rat
亚型
Rat IgG2a, k
性状
Liquid
纯化方法
affinity purified by Protein G
克隆类型
Monoclonal
克隆号
2C8
理论分子量
15 kDa
检测分子量
18-25 kDa
储存液
0.01M PBS (pH7.4), 0.5% BSA, 0.02% Proclin300.
保存条件
Store at 2-8℃. Protect from light. Avoid freezing.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍
IL-2作为一种T细胞生长因子在免疫应答及其调节中起重要作用,IL-2的拮抗剂可用于同种移植排斥、T细胞性白血病以及某些自身免疫性疾病的治疗.胞内IL-2的水平是反映Th1 /Th2型细胞平衡状态的一个有用指标,血清IL-2的水平异常增高与某些疾病密切相关
背景资料
The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008]

产品应用

应用已检合格种属预测种属推荐稀释比例
Flow-CytHuman10ul/Test

交叉反应

交叉反应: (predicted: Human)

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靶标

基因名
IL2
蛋白名
Interleukin-2
亚细胞定位
Secreted.
疾病
Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.
相似性
Belongs to the IL-2 family.
功能
Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.

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