RRM2 Recombinant Mouse mAb (一抗) - WB,ICC/IF | Bioss

bsm-60351M

重组小鼠单抗

RRM2 Recombinant Mouse mAb

核糖核苷酸还原酶亚基R2重组小鼠单抗

C2orf48; R2; RR2; RR2M; RIR2_HUMAN; RRM2; Ribonucleotide reductase small chain; Ribonucleotide reductase small subunit; 1.17.4.1;

Mouse

IgG1, Kappa

Liquid

affinity purified by Protein G

Recombinant

G9B7

42 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Ribonucleotide reductase is essential for the production and maintenance of the level of deoxyribonucleoside triphosphates (dNTPs) required for DNA synthesis. It is an enzymatic complex consisting of two nonidentical subunits, R1 and R2, which are inactive separately. R2, the smaller subunit, is localized to the cytoplasm. R2 is the limiting factor of the catalytic activity of the ribonucleotide reductase enzymatic complex. R2 expression is strictly correlated to the S-phase of the cell cycle, whereas R1 remains constant throughout all phases of the cell cycle. While R2 seems to be involved solely in the maintenance of dNTPs for DNA replication, a similar protein, p53R2, has been shown to be responsible for the production of dNTPs in response to DNA damage. Function : Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling.