DAP-4; DAP4; DLP4; SAPAP-4; SAPAP4; WBP16; DLGP4_HUMAN; DLGAP4; PSD-95/SAP90-binding protein 4; SAP90/PSD-95-associated protein 4 (SAPAP-4); KIAA0964; DLGP4_MOUSE; DLGP4_RAT; DLG associated protein 4; discs, large (Drosophila) homolog-associated protein 4; discs large homolog associated protein 4
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human SAPAP4/DLGAP4: 261-370/992
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
108 kDa
检测分子量
108 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
A guanylate kinase is a phosphotransferase that produces ADP and GDP from the substrates ATP and GMP. SAPAP4 is a 992 amino acid protein that likely localizes to the postsynaptic membrane of neurons to enhance neuronal signaling. SAPAP4 could act as a signaling molecule which interacts with the human genes DLG1 and DLG4/PSD-95. The gene encoding SAPAP4, DLGAP4, maps to human chromosome 20. Comprising approximately 2% of the human genome, chromosome 20 contains nearly 63 million bases that encode over 600 genes, some of which are associated with Creutzfeldt-Jakob disease, amyotrophic lateral sclerosis, spinal muscular atrophy, ring chromosome 20 epilepsy syndrome and Alagille syndrome. Additionally, chromosome 20 contains a region with numerous genes which are thought important for seminal production and may be potential targets for male contraception.
产品应用
应用
已检合格种属
预测种属
推荐稀释比例
WB
Mouse
Human, Rat, Rabbit, Pig, Sheep, Cow, Dog, GuineaPig, Horse
Interacts with DLG1 and DLG4/PSD-95 (By similarity).
亚细胞定位
Membrane; Peripheral membrane protein (By similarity).
相似性
Belongs to the SAPAP family.
功能
May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.