This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs. This protein also constitutes a monomer of the N-acetylglucosamine-specific receptor which is postulated to trigger selective recycling of immature GlcNAc-bearing thyroglobulin molecules. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
产品应用
应用
已检合格种属
预测种属
推荐稀释比例
IHC-P
Human, Mouse, Rat
Dog, Horse
1:100-500
IHC-F
Human, Mouse, Rat
Dog, Horse
1:100-500
IF
Human, Mouse, Rat
Dog, Horse
1:100-500
交叉反应
交叉反应: Human, Mouse, Rat (predicted: Dog, Horse)
相关产品
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靶标
基因名
HNRNPM
蛋白名
Heterogeneous nuclear ribonucleoprotein M
亚基
Identified in the spliceosome C complex.
亚细胞定位
Nucleus, nucleolus.
翻译后修饰
Sumoylated.
相似性
Contains 3 RRM (RNA recognition motif) domains.
功能
Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines.