MUL1 Rabbit pAb (一抗) | Bioss
货号：bs-9291R
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概述
产品编号
bs-9291R
产品类型
宠物抗体、农牧业/家禽抗体
英文名称
MUL1 Rabbit pAb
中文名称
E3泛素连接酶MUL1抗体
英文别名
C1orf166; GIDE; MAPL; MULAN; RNF218; 0610009K11Rik; RGD1309944; MUL1_HUMAN; MUL1; E3 SUMO-protein ligase MUL1; E3 ubiquitin-protein ligase MUL1; Growth inhibition and death E3 ligase; Mitochondrial-anchored protein ligase; Protein Hades; Putative NF-kappa-B-activating protein 266; RING finger protein 218; RING-type E3 ubiquitin transferase NFKB 1; 2.3.2.27; MUL1_MOUSE;
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human MUL1/RNF218: 1-100/352
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
40 kDa
检测分子量
40 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
E3 ubiquitin-protein ligase that plays a role in the control of mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localization. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Mouse | Human, Rat, Rabbit, Pig, Cow, Dog | 1:500-2000 |
| IHC-P | Rat | Human, Mouse, Rabbit, Pig, Cow, Dog | 1:100-500 |
| IHC-F | Rat | Human, Mouse, Rabbit, Pig, Cow, Dog | 1:100-500 |
| IF | Mouse, Rat | Human, Rabbit, Pig, Cow, Dog | 1:100-500 |
| Flow-Cyt | Human | Mouse, Rat, Rabbit, Pig, Cow, Dog | 1ug/test |
交叉反应
交叉反应: Human, Mouse, Rat (predicted: Rabbit, Pig, Cow, Dog)
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靶标
基因名
MUL1
蛋白名
Mitochondrial ubiquitin ligase activator of NFKB 1
亚基
Homooligomer. Interacts with MAP3K7/TAK1. Interacts with UBC9. Interacts with and sumoylates DNM1L.
亚细胞定位
Mitochondrion outer membrane; Multi-pass membrane protein. Peroxisome. Note: Transported in mitochondrion-derived vesicles from the mitochondrion to the peroxisome.
组织特异性
Widely expressed with highest levels in the heart, skeletal muscle, placenta, kidney and liver. Barely detectable in colon and thymus.
相似性
Contains 1 RING-type zinc finger.
功能
Exhibits weak E3 ubiquitin-protein ligase activity, but preferentially acts as a SUMO E3 ligase at physiological concentrations. Plays a role in the control of mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localization. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
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