CSF1 Rabbit pAb (一抗) | Bioss

bs-4910R

宠物抗体、农牧业/家禽抗体

CSF1 Rabbit pAb

巨噬细胞克隆刺激因子抗体

CSF-1; MCSF; PG-M-CSF; BAP025; Csfm; Mhdabap25; op; CSF1_HUMAN; CSF1; M-CSF; Lanimostim; Proteoglycan macrophage colony-stimulating factor (PG-M-CSF); CSF1_MOUSE; CSF1_RAT;

Rabbit

KLH conjugated synthetic peptide derived from human MCSF/M-CSF: 201-300/554 <Extracellular>

IgG

Liquid

affinity purified by Protein A

Polyclonal

57 kDa

57 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

M-CSF是促使造血细胞分化成粒细胞与巨噬细胞克隆的重要细胞因子,对正常血细胞的形成与造血细胞 的存活、分化、正常造血功能 的维持具有重要作用,直接与间接增加lak细胞的活性,在人体 的细胞因子网络中占有重要 的地位,目前广泛应用于化.放疗 的辅助治疗中。
目前研究主要应用在免疫缺陷性疾病及病毒性疾病：慢性肝病,尤其是与病毒相关的疾病,因其发病过程涉及免疫细胞与造血系统,有可能成为gm-csf(粒细胞-巨噬细胞克隆刺激因子)应用的新领域。人和小鼠天然M-CSF为糖蛋白，由二硫键连接的同源双体，分子量40～90kDa。人和小鼠M-CSF分子这个区域结构高度保守，其同源性达80％。

Four distinct colony-stimulating factors (CSFs) that promote survival, proliferation and differentiation of bone marrow precursor cells have been well characterized: granulocyte macrophage CSF (GMCSF), granulocyte CSF (GCSF), macrophage CSF (MCSF), and Interleukin-3 (IL-3, Multi CSF). Both GMCSF and IL-3 are multipotential growth factors, stimulating proliferation of progenitor cells from more than one hematopoietic lineage. In contrast, GCSF and MCSF are lineage restricted hematopoietic growth factors, stimulating final mitotic divisions and the terminal cellular maturation of the partially differentiated hematopoietic progenitors.
Macrophage CSF, also known as CSF1, is produced by monocytes, fibroblasts and endothelial cells. It stimulates the formation of macrophage colonies, enhances antibody-dependent, cell-mediated cytotoxicity by monocytes and macrophages, and inhibits bone resorption by osetoclasts. Natural human MCSF is a dimeric glycoprotein of 70-90 kD molecular weight, existing in multiple glycosylation forms. It binds to a 165 kD glycoprotein of the receptor tyrosine kinase subclass III, a family that includes the receptors for platelet derived growth factor (PDGF) and stem cell factor (SCF).