APC标记的CD86抗体

2026-01-04~2026-02-28，ZB1888

一键复制说明书文献引用(10)

货号：bs-1035R-APC

产品详情

概述

产品编号

bs-1035R-APC

英文名称

CD86 Rabbit pAb, APC conjugated

中文名称

APC标记的CD86抗体

英文别名

CD28LG2; FUN1; LAB72; Activation B7 2 antigen; Activation B7-2 antigen 3; CD86_HUMAN; Activation B7-2 antigen; Activation B72 antigen; B lymphocyte activation antigen B7 2; B lymphocyte activation antigen B72; B-lymphocyte activation antigen B7-2 2; B-lymphocyte activation antigen B7-2; B7 2; B7 2 antigen; B7; B7-2; B7.2; B70; B72 antigen; BU63; CD 86; CD28 antigen ligand 2 2; CD28 antigen ligand 2; Cd28l2; CD28LG2; CD86 antigen(CD28 antigen ligand 2, B7-2 antigen) 1, 2; CD86 antigen; CD86 molecule; CLS1; CTLA 4 counter receptor B7 2; CTLA 4 counter receptor B7.2; CTLA-4 counter-receptor B7.2 2, 3; CTLA4 counter receptor B72; Early T-cell costimulatory molecule 1; ETC-1; FUN 1; LAB72; Ly-58; Ly58; MB7; MB7-2; Membrane glycoprotein; MGC34413; T lymphocyte activation antigen CD86; T-lymphocyte activation antigen CD86; TS/A-2.

标记

APC
Excitation spectrum: 650nm
Emission spectrum: 660nm

抗体来源

Rabbit

免疫原

KLH conjugated synthetic peptide derived from the middle of rat CD86: 140-175/313 <Extracellular>

亚型

IgG

纯化方法

affinity purified by Protein A

克隆类型

Polyclonal

浓度

1mg/ml

储存液

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Gene ID

56822

保存条件

Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

注意事项

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

数据库链接

Entrez Gene : 942 Human

Entrez Gene : 56822 Rat

Omim : 601020 Human

SwissProt : P42081 Human

Unigene : 171182 Human

Unigene : 229570 Rat

SwissProt : P42082 Mouse

Entrez Gene : 12524 Mouse

产品介绍

CD86是一个很重要要的辅助刺激分子，CD86作为CD28的辅助刺激分子，提供 T 细胞活化的辅助信号,它们之间的结合和随后介导的信号转导是 T 细胞和 APC 相互协作的重要分子基础。

背景资料

This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011].

产品应用

应用	已检合格种属	预测种属	推荐稀释比例
IF		Human, Mouse, Rat	1:100-500
Flow-Cyt		Human, Mouse, Rat	1ug/Test

交叉反应

交叉反应: Human, Mouse, Rat

靶标

基因名

CD86

蛋白名

T-lymphocyte activation antigen CD86

亚基

Homodimer. Interacts with MARCH8. Interacts with human herpesvirus 8 MIR2 protein (Probable). Interacts with adenovirus subgroup B fiber proteins and acts as a receptor for these viruses.

亚细胞定位

Cell membrane; Single-pass type I membrane protein.

组织特异性

Expressed by activated B-lymphocytes and monocytes.

翻译后修饰

Polyubiquitinated; which is promoted by MARCH8 and results in endocytosis and lysosomal degradation.

相似性

Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.

功能

Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.

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APC标记的CD86抗体

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