GLUT4 Rabbit pAb (一抗) - WB | Bioss
货号：bs-0384R
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概述
产品编号
bs-0384R
产品类型
宠物抗体、农牧业/家禽抗体
英文名称
GLUT4 Rabbit pAb
中文名称
葡萄糖转运蛋白4抗体
英文别名
GLUT4; GT2; Glut-4; twgy; GLUT4_BOVIN; SLC2A4; Glucose transporter type 4, insulin-responsive (GLUT-4); Q29RP5_BOVIN; GLUT4_HUMAN; GLUT4_MOUSE; GLUT4_RAT;
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human GLUT4: 401-509/509 <Cytoplasmic>
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
54 kDa
检测分子量
50 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
Cancer > Cancer Metabolism > Metabolic signaling pathway > Metabolism of carbohydrates
Cardiovascular > Heart > Cardiac metabolism
Metabolism > Pathways and Processes > Metabolic signaling pathways > Carbohydrate metabolism
Metabolism > Pathways and Processes > Metabolic signaling pathways > Energy transfer pathways > Energy Metabolism
Metabolism > Types of disease > Diabetes
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
葡萄糖转运蛋白-4是一种十分重要的葡萄糖转运体,与胰岛素抵抗和2型糖尿病密切相关.葡萄糖转运蛋白4在细胞内部和细胞膜之间循环流动.实现对葡萄糖的转运需要葡萄糖转运蛋白4自身的转位和活化.葡萄糖转运蛋白4与肥胖、肿瘤相关联.
GLUT-2和GLUT-4蛋白这两个葡萄糖运载体的研究对于糖尿病的胰岛素释放障碍和胰岛素抵抗有重要意义.
GLUT-2和GLUT-4蛋白这两个葡萄糖运载体的研究对于糖尿病的胰岛素释放障碍和胰岛素抵抗有重要意义.
背景资料
GLUT4 is the facilitated glucose transporter expressed exclusively in adipocytes and muscle cells, and is also known as the "insulin-responsive" glucose transporter. GLUT4 translocates from an ill-defined intracellular compartment to the plasma membrane in response to insulin. The total cellular content of GLUT4 is significantly decreased in adipose cells from many patients with Type II diabetes mellitus, and animals with some types of experimental diabetes.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Mouse, Rat | Human, Rabbit, Pig, Sheep, Cow, Dog | 1:500-2000 |
交叉反应
交叉反应: Mouse, Rat (predicted: Human, Rabbit, Pig, Sheep, Cow, Dog)
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靶标
基因名
SLC2A4
蛋白名
Solute carrier family 2, facilitated glucose transporter member 4
亚细胞定位
Endomembrane system. Cytoplasm > perinuclear region. Localizes primarily to the perinuclear region, undergoing continued recycling to the plasma membrane where it is rapidly reinternalized. The dileucine internalization motif is critical for intracellular sequestration.
组织特异性
Skeletal and cardiac muscles; brown and white fat.
翻译后修饰
Sumoylated.
疾病
Defects in SLC2A4 may be a cause of noninsulin-dependent diabetes mellitus (NIDDM) [MIM:125853]. Defects in SLC2A4 may be a cause of certain post-receptor defects in NIDDM. The variant in position Ile-383 is found in a small number of NIDDM patients, but seems not to be found in nondiabetic subjects.
相似性
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
功能
Insulin-regulated facilitative glucose transporter.
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