GRID2IP Rabbit pAb (一抗) | Bioss

bs-11347R

宠物抗体、农牧业/家禽抗体

GRID2IP Rabbit pAb

谷氨酸受体δ2/GluR-δ2抗体

DELPHILIN; GRD2I_HUMAN; GRID2IP; Glutamate receptor, ionotropic, delta 2-interacting protein 1; Grid2 interacting protein; glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 1; glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein

Rabbit

KLH conjugated synthetic peptide derived from human GRID2IP: 921-1020/1121

IgG

Liquid

affinity purified by Protein A

Polyclonal

132 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Grid2ip is a postsynaptic scaffolding protein that contains one formin homology 2 (FH2) domain and two PDZ (postsynaptic density-95/discs-large/ZO-1) domains. Expressed in Purkinje cells of the cerebellum and localizing specifically to parallel fiber synapses, Grid2ip interacts with the C-terminus of GluR-Delta 2 and, via this interaction, links GluR-Delta 2 with various signaling molecules and the Actin cytoskeleton. GluR-Delta 2 is a glutamate receptor with an important role in motor learning, cerebellar wiring and synaptic plasticity. Due to alternative splicing events, three Grid2ip isoforms exist, namely L-delphilin, S-delphilin (or delphilin-Alpha) and delphilin-Beta. Each isoform exhibits individual expression patterns and protein interactions. Isoform 2, delphilin-Alpha, is palmytoylated, a modification that is essential for the enhanced expression of GluR-Delta 2 on the cell surface. This modification of delphilin-Alpha also mediates the accumulation of delphilin-Alpha in dendritic spines.