NALP4 Rabbit pAb (一抗) | Bioss
货号：bs-6855R
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概述
产品编号
bs-6855R
产品类型
农牧业/家禽抗体
英文名称
NALP4 Rabbit pAb
中文名称
癌/睾丸抗原58抗体
英文别名
CLR19.5; CT58; NALP4; PAN2; PYPAF4; RNH2; Nlrp4e; RGD1563529; RGD1564841; NALP4_HUMAN; NLRP4; Cancer/testis antigen 58 (CT58); PAAD and NACHT-containing protein 2 (PAN2); PYRIN and NACHT-containing protein 2; PYRIN-containing APAF1-like protein 4 (PYPAF4); Ribonuclease inhibitor 2;
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human NALP4: 351-450/994
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
113 kDa
检测分子量
113 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
The protein encoded by this gene is a member of the nucleotide-binding and leucine-rich repeat receptor (NLR) family, and is predicted to contain an N-terminal pyrin effector domain (PYD), a centrally-located nucleotide-binding and oligomerization domain (NACHT) and C-terminal leucine-rich repeats (LRR). This gene product has a demonstrated role as a negative regulator of autophagy and type I interferon signaling pathways as a result of protein interactions with its NACHT domain. The PYD domain has also been shown to be important in the inhibition of NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells). [provided by RefSeq, Dec 2016]
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Mouse, Rat | Human, Pig, Horse | 1:500-2000 |
| IHC-P | Human | Mouse, Rat, Pig, Horse | 1:100-500 |
| IHC-F | Human | Mouse, Rat, Pig, Horse | 1:100-500 |
| IF | Human | Mouse, Rat, Pig, Horse | 1:100-500 |
交叉反应
交叉反应: Human, Mouse, Rat (predicted: Pig, Horse)
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靶标
基因名
NLRP4
蛋白名
NACHT, LRR and PYD domains-containing protein 4
亚基
Associates with the subcortical maternal complex (SCMC) composed of at least NLRP5, KHDC3, OOEP, and TLE6 via interaction with OOEP and TLE6.
亚细胞定位
Cytoplasm and Cytosol
组织特异性
Expressed in the ovaries (at protein level).
相似性
Belongs to the NLRP family.
Contains 1 DAPIN domain.
Contains 8 LRR (leucine-rich) repeats.
Contains 1 NACHT domain.
Contains 1 DAPIN domain.
Contains 8 LRR (leucine-rich) repeats.
Contains 1 NACHT domain.
功能
Required for cytoplasmic lattice formation, thereby modulates the distribution of organelles during oocyte maturation and zygote development
Required for preimplantation development in female fertility
May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors (By similarity).
Required for preimplantation development in female fertility
May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors (By similarity).
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